Table 1.

Summary of the characteristics of the patient tumor and corresponding PDTX model^*

	Well-moderately differentiated (PAC006)	Poorly differentiated (PAC010)
Patient background	Primary tumor biopsy (EUS-FNA) from 85 years old women.	Primary tumor biopsy (EUS-FNA) from 83 years old man.
Patient tumor pathology	Pancreatic ductal adenocarcinoma, grows as irregular glandular structures in a desmoplastic stroma & locally, cribriform patterns. Tumor cells have enlarged, atypical and hyperchromatic nuclei.	Pancreatic ductal adenocarcinoma, metastases in liver. Tumor cells have large atypical and pleiomorphic nuclei on a background of necrosis.
Treatment history	None.	None.
PDTX tumor pathology	Pancreatic ductal adenocarcinoma, irregular glandular structures, cells with atypical nuclei and prominent nucleolus.	Large tumor cells with atypical nuclei and often prominent nucleolus.
Genomic profiling	RNA sequencing , Whole exome sequencing, Sequenom MassArray for KRAS, Shallow sequencing (copy number) (only PDX model, not human tumor).	RNA sequencing, Sequenom MassArray for KRAS, Shallow sequencing (copy number), Whole exome sequencing (only PDX model, not human tumor).
Oncogene mutation status	KRAS p.G12D, TP53 wildtype.	KRAS p.G12D, KRAS double amplified, TP53 p.R175H, TP53 homozygous deficient.

^*Adapted from: Hermans et al., 2016 [9].