Table 4.
Top upstream regulators and functions identified by IPA using information from differentially expressed genes of PAC010 in response to GEM treatment
| A. | |||
|
| |||
| Upstream Regulator | Molecule Type | Predicted Activation State* | p-value of overlap |
|
| |||
| CBX5 | Transcription regulator | Inhibited | 2,43E-13 |
| STAT5A | Transcription regulator | 5,04E-11 | |
| VEGF | Group | 3,04E-08 | |
| S100A9 | Other | Activated | 6,06E-08 |
| IL1B | Cytokine | 4,25E-07 | |
| SMARCA4 | Transcription regulator | 5,12E-07 | |
| TNF | Cytokine | Activated | 7,52E-07 |
| CHUK | Kinase | Activated | 1,25E-06 |
| JUN | Transcription regulator | Activated | 2,00E-06 |
| TREM1 | Transmembrane receptor | Activated | 2,89E-06 |
|
| |||
| B. | |||
|
| |||
| Diseases or Functions Annotation | p-Value | Predicted Activation State* | #Molecules |
|
| |||
| Cell movement of phagocytes | 1,27E-05 | 32 | |
| Leukocyte migration | 1,85E-05 | 44 | |
| Cellular infiltration by phagocytes | 2,66E-05 | 19 | |
| Cell movement of myeloid cells | 2,91E-05 | 31 | |
| Cellular infiltration by granulocytes | 3,63E-05 | 16 | |
| Attraction of blood cells | 3,88E-05 | 8 | |
| Cellular infiltration by myeloid cells | 4,40E-05 | 20 | |
| Cell movement of leukocytes | 5,29E-05 | 39 | |
| Attraction of granulocytes | 8,51E-05 | 5 | |
| Transmigration of leukocytes | 8,67E-05 | 11 | |
*
blank = IPA analysis did not assign activation status (both up and down regulatory factors).
#
Molecules: number of genes from differentially expressed gene list linked to disease or function.
A) List of top 10 upstream regulatory molecules, their predicted activation state and p-value; B) List of top 10 diseases and cellular functions detected # Molecules: number of genes from differentially expressed gene list linked to disease or function.