Metformin attenuates NLRP3 inflammasome activation in the wound via activating the AMPK. A, B. Representative images and quantitation of the western blot showing the protein expression of p-AMPK, AMPK. The original images are available in Figure S2. C, D. Representative images and quantitation of the western blot showing the protein expression of NLRP3, Pro-IL-1β, IL-1β, Pro-caspase-1, caspase-1. The original images are available in Figure S2. Data are presented as the mean ± SEM. *P<0.05 vs. Con or Cpd C group, **P<0.01 vs. Cpd C group. Ctrl, control; Met, metformin; Cpd C, compound C.