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. Author manuscript; available in PMC: 2019 Apr 16.
Published in final edited form as: Chem Res Toxicol. 2018 Mar 28;31(4):269–276. doi: 10.1021/acs.chemrestox.7b00326

Figure 4.

Figure 4.

Curcumin autoxidation and adduct formation in relation to the time point of thiol addition. GSH, NAc, and βME (1 mM) were either present form the start (0 min) or added 20 min after the start (20 min) of autoxidation of curcumin (50 μM) for a total reaction time of 1 h. (A) Peak areas for curcumin and dioxygenated curcumin (BCP and other products). (B) Peak areas of curcumin-thiol and dioxygenated curcumin-thiol adducts. Negative ion LC-MS analyses were performed as described in “Experimental Procedures”. The mean of three independent experiments (± SD) is shown.