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. Author manuscript; available in PMC: 2019 Dec 7.
Published in final edited form as: J Mol Biol. 2018 Oct 26;430(24):5050–5065. doi: 10.1016/j.jmb.2018.10.014

Table 1.

pKa values of binding site glutamates and aspartates. The numbers in the parentheses represent the pKa values from the other chain in the crystal structure unit cell. The program PROPKA3.1 [33] is used to compute the pKa values of the titratable residues.

Resolution (Å) Nucleotide Ligand E309 E771 D800 E908
1IWO 3.1 None TG1 6.4(6.4) 10.8(10.8) 6.8(6.8) 10.1(10.1)
2AGV 2.4 None TG1,BHQ 9.0(9.0) 10.9(10.9) 8.2(8.2) 9.7(9.8)
2BY4 3.3 AMPPCP AD4 9.8 11.6 7.5 9.5
2C88 3.1 AMPPCP TG1 9.4 10.7 7.2 10.0
2C8K 2.8 AMPPCP TG1 9.0 10.5 7.8 10.0
2C8L 3.1 None TG1 9.2 10.7 7.9 10.0
2DQS 2.5 AMPPCP TG1 8.6 9.7 8.2 10.3
2EAR 3.1 None TG1 8.3 10.5 8.0 9.9
2EAT 2.9 None TG1,CZA 8.7 10.3 7.0 11.6
2EAU 2.8 None CZA 9.7 10.8 7.2 9.6
2YFY 3.1 None 9TN 9.4 11.4 7.6 9.6
3AR3 2.3 ADP TG1 9.1 10.9 7.8 9.8
3AR4 2.15 ATP TG1 9.0 10.9 8.3 9.9
3AR5 2.2 TM1 TG1 8.9 10.9 8.2 9.8
3AR6 2.2 12D TG1 8.9 10.9 8.0 10.0
3AR7 2.15 128 TG1 8.9 10.8 7.8 9.7
3FPS 3.2 ADP CZA 11.3 9.4 11.1 7.4
3NAL 2.65 None DBK 9.1 10.8 7.5 10.2
3NAM 3.1 None OTK 8.6 10.8 7.3 10.2
3NAN 3.1 None HZ1 8.9 10.8 8.0 10.1
3W5C 2.5 None None 9.7 11.1 7.3 9.4
4UU0 2.5 TBU,SO4 TG1 9.3 11.2 7.9 9.7
4UU1 2.8 AMPPCP TG1 8.6 11.0 7.3 9.8
4YCL 3.3 None CZA 9.2 11.2 7.7 10.5
4YCM 3.2 None 7BS 9.3 11.4 7.9 10.0
4YCN 3.5 None 7BL 10.1 10.8 7.1 11.1
5XAB 3.2 None TG1 9.1 11.2 7.9 10.0