Fig. 3.
Contributions from inactivation of the MEN1 gene in groups with common variety endocrine tumour (i.e. no DNA or kindred evidence of MEN1). Inactivation of the MEN1 gene is found as small mutations in the MEN1 gene sequence and as large subchromosomal losses, the latter determined by loss of heterozygosity at 11q13. Modified from Gagel and Marx [2].