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In vitro kinase inhibition activity of select compounds. Inhibition of (a) FLT3-ITD (100 nM) and (b) Src (0.6 nM) by HSN431 and HSN459. IC50 values of each compound are shown in parenthesis. ATP concentration was 100 μM. Substrates used and substrate concentrations are presented in Table S1. Each data point represents the mean ± SD of duplicate measurements.
