White matter networks in DM1 patients versus controls. I. Topological cluster that significantly differed between DM1 patients and unaffected controls (p-value adjusted <0.05, threshold t = 2.4 (corresponding with p-uncorrected 0.025). Networks were projected on the MNI152 standard space template, and visualized from the axial plane in neurological convention using the BrainNet Viewer toolbox in MATLAB.(Xia et al., 2013) a: anterior, p: posterior, r: right, l: left. Panel A: left lateral view. Panel B: Axial view from top. Panel C: right lateral view. II. Connection strength of rich club, feeder and peripheral connections of DM1 patients relative controls. Connections strength in DM1 patients was lower than in controls (see text); there were no statistically significant differences in connection strength between the 3 connection types within the DM1 patient group.