Table 1.

Demographic and clinical parameters.

Variable	DM1 patients	Unaffected controls	P-value
Sex, no. of men/women	13/15	15/11	0.785
Age, mean in years ± SD	46.0 ± 9.0	50.2 ± 12.4	0.167
Educational level, mean ± SD	5.4 ± 1.0	5.4 ± 0.7	0.803
Functional vital capacity* (L), mean ± SD	3.3 (0.9)	4.4 (1.0)	0.0001
Estimated CTG progenitor allele length, mean ± SD ^	250.12 ± 140.57	N/A	N/A
Modal CTG repeat length, mean ± SD^	441.84 ± 210.33	N/A	N/A
Age at onset in years, mean ± SD^	24.1 ± 12.1	N/A	N/A
Clinical disease classification, no. (%) of patients with cDM1, iDM1, jDM1, aDM1, loDM1	0 (0), 1 (4), 12 (43), 12 (43), 2 (7)#	N/A	N/A
AES-c score^, mean ± SD	36.0 ± 7.9	N/A	N/A
DM1-activ-c^, mean ± SD	65.5 ± 15.7	N/A	N/A
CIS-fatigue^, mean ± SD	40.9 ± 7.5	N/A	N/A
MDHI^, mean ± SD	26.4 ± 15.0	N/A	N/A
MIRS score, no. (%) of patients^: 1/2/3/4/5	2 (7), 3 (11), 20 (71), 3 (11), 0 (0)	N/A	N/A
BDI-fs^ score, median [IQR]	2.0 [3.0]	N/A	N/A

^ Data collected in OPTIMISTIC main study; *sitting position. cDM1: congenital onset DM1; iDM1: infantile onset DM1, jDM1: juvenile onset DM1; aDM1 adult onset DM1; loDM1: late-onset DM1.(De Antonio et al., 2016) #for one patient, age at onset of symptoms was unknown. AES-c: apathy evaluation scale, clinician version, CIS-fatigue: checklist individual strength, fatigue subscale; MDHI: myotonic dystrophy health index; MIRS: muscular impairment rating scale; BDI-fs: Beck depression inventory fast-screen.