Table 2.
Neuropsychological test results in patients and controls: raw scores, p-values and effect sizes.
| Cognitive test | Dir. of score | DM1 patients Mean (SD) or Median [IQR] | Unaffected controls Mean (SD) or Median [IQR] | P-Valueb | Effect sizea |
|---|---|---|---|---|---|
| NART-IQ | ↑ | 97.2 (15.2) | 98.7 (17.4) | 0.741 | 0.1 |
| RPM | ↑ | 8.6 (2.0) | 9.5 (1.7) | 0.083 | 0.5 |
| LM I | ↑ | 31.0 [7.5] | 27.5 [7.0] | 0.202 | 0.3 |
| LM II | ↑ | 26.6 (6.1) | 24.4 (6.2) | 0.183 | 0.4 |
| Category fluency (animals) | ↑ | 27.4 (5.2) | 25.9 (7.6) | 0.400 | 0.2 |
| Category fluency (occupations) | ↑ | 21.2 (4.2) | 20.9 (6.3) | 0.839 | 0.1 |
| TMT Interference score | ↑ | 0.39 [0.11] | 0.44 [0.15] | 0.097 | 0.2 |
| Stroop Color Word Test Interference score | ↑ | 0.64 [0.10] | 0.70 [0.10] | 0.008c | 0.7 |
| Brixton Spatial Anticipation Test | ↓ | 15.5 [5.5] | 15.0 [9.0] | 0.223 | 0.5 |
| d2 test (Tn-F) | ↑ | 334.0 [86.5] | 405.5 [129.0] | 0.0005c | 1.0 |
| ROCF copy | ↑ | 30.0 [6.7] | 31.0 [4.3] | 0.037c | 0.7 |
| ROCF ir/copy | ↑ | 0.63 [0.28] | 0.74 [0.19] | 0.040c | 0.5 |
| ROCF dr/copy | ↑ | 0.65 [0.27] | 0.75 [0.21] | 0.100 | 0.4 |
| Pegboard | ↑ | 8.3 [5.5] | 10.0 [2.5] | 0.009c | 0.9 |
dir: direction; NART: National adult reading test – IQ estimate; RPM: Raven's progressive matrices; LM I and LM II: Logical Memory of WSM-IV; ROCF: Rey-Osterrieth Complex Figure Test; IQR: interquartile range.
a
Cohen's d is used as a measure of effect size, provided is the absolute effect size.
b
Calculated using independent t-tests and non-parametric Mann-Whitney U tests for normally and non-normally distributed data. p-values <.05 are bold.
c
All results remained significant after application of the Benjamini-Hochberg procedure with false-discovery rate Q set at 0.15.