Table 3.
MRI analyses.
| DM1 | Unaffected controls | p-value | |
|---|---|---|---|
| White matter lesion loada | N = 24 | N = 26 | |
| Fazekas: periventricular white matter | 2 ± 0.76 | 0.92 ± 0.56 | p < .0001 |
| mean ± SD, score 0/1/2/3 | 0 / 7 / 11 / 7 | 5 / 18 / 3 / 0 | |
| Fazekas: deep white matter | 1.16 ± 0.69 | 0.58 ± 0.50 | p < .0001 |
| mean ± SD, score 0/1/2/3 | 3 / 16 / 5 /1 | 11 / 15 / 0 / 0 | |
| ARWMC | 1.6 ± 0.65 | 0.54 ± 0.51 | p < .0001 |
| mean ± SD, score 0/1/2/3 | 0 / 12 / 11 / 2 | 12 / 14 / 0 / 0 | |
| ARWMC basal ganglia | 0.28 ± 0.61 | 0.19 ± 0.58 | p = 0.539 |
| mean ± SD, score 0/1/2/3 | 20 / 3 / 2 / 0 | 23 / 1 / 2 / 0 | |
| Volumetryb | N = 23 | N = 26 | |
| Average grey matter volume – mean (SD) | 619.8 (78.9) | 690.6 (81.8) | p = 0.0005 |
| Average white matter volume – mean (SD) | 453.4 (58.4) | 465.8 (61.9) | p = 0.611 |
| Average CSF volume – mean (SD) | 406.9 (91.7) | 416.1 (62.4) | p = 0.660 |
| Diffusion tensor imagingb | N = 23 | N = 26 | |
| FA – mean (SD) | 0.50 (0.02) | 0.56 (0.02) | p < 0.0001 |
| MD – mean (SD) | 0.08e−2 (0.03e−3) | 0.07e−2 (0.03e−3) | p < 0.0001 |
| Structural white matter networksb | N = 22 | N = 22 | |
| Density – mean (SD) | 0.0985 (0.00537) | 0.0973 (0.00335) | p = 0.312 |
| Strength – mean (SD) | 0.0383 (0.01238) | 0.0509 (0.00887) | p < 0.0001 |
| Global efficiency – mean (SD) | 0.0023 (0.00072) | 0.0031 (0.00053) | p < 0.0001 |
| Local efficiencyc−mean (SD) | 0.0019 (0.00054) | 0.0025 (0.00041) | p < 0.0001 |
White-matter hyperintensities in DM1 patients and control as measured with Fazekas and ARWMC scales.
a
Likelihood ratio test.
b
univariate GLM analysis p-value after correction for age, sex and educational level.
c
Mean average across nodes.