Figure 4.

Histologic features and scoring for structural damage in mouse knee articular cartilage at 8 weeks following destabilization of the medial meniscus (DMM) model. OA was induced in C57BL/6N mice following surgical DMM, SA or vehicle was orally delivered every other day (10mg/kg) postoperatively. (a) Representative frontal sections (6 μm) were stained with Safranin O/Fast Green (n=10 per group). Triangular symbol indicates the affected cartilage areas. Scale bars = 100 μ m. (b) OARSI scoring of OA. ∗p < 0.05.