Table 1.
Genotype frequencies, HWE tests, and single-SNP association analyses of 30 RELN SNPs in the SZ and control cases.
| dbSNP ID | Allele (D/d)a | Case |
Control |
Genotype (p)e | Allele (P)e | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| nb | HWE (p)c | Genotype |
MAFd | nb | HWE (p)c | Genotype |
MAFd | ||||||||
| DD | Dd | dd | DD | Dd | dd | ||||||||||
| rs11764507 | G/A | 100 | 0.068 | 72 | 22 | 6 | 0.170 | 161 | 0.381 | 106 | 52 | 3 | 0.180 | 0.062 | 0.768 |
| rs17157643 | T/A | 100 | 1.000 | 78 | 21 | 1 | 0.115 | 162 | 0.734 | 137 | 25 | 0 | 0.077 | 0.213 | 0.145 |
| rs6465938 | C/T | 100 | 0.046 | 40 | 38 | 22 | 0.410 | 163 | 0.388 | 60 | 83 | 20 | 0.377 | 0.048 | 0.455 |
| rs39339 | A/C | 100 | 0.416 | 77 | 20 | 3 | 0.130 | 162 | 0.714 | 126 | 35 | 1 | 0.114 | 0.283 | 0.589 |
| rs155333 | G/A | 100 | 0.123 | 54 | 34 | 12 | 0.290 | 162 | 0.546 | 78 | 72 | 12 | 0.296 | 0.201 | 0.878 |
| rs262355 | T/A | 99 | 0.071 | 55 | 32 | 12 | 0.283 | 162 | 0.700 | 80 | 70 | 12 | 0.290 | 0.173 | 0.858 |
| rs1510846 | T/C | 95 | 0.834 | 29 | 49 | 17 | 0.437 | 162 | 0.210 | 50 | 72 | 40 | 0.469 | 0.408 | 0.478 |
| rs11496125 | C/T | 98 | 1.000 | 36 | 47 | 15 | 0.393 | 162 | 0.447 | 65 | 71 | 26 | 0.380 | 0.850 | 0.764 |
| rs10435342 | C/T | 100 | 0.277 | 85 | 13 | 2 | 0.085 | 163 | 0.995 | 143 | 19 | 1 | 0.064 | 0.599 | 0.376 |
| rs661575 | C/T | 99 | 0.131 | 51 | 34 | 14 | 0.308 | 163 | 0.072 | 81 | 60 | 22 | 0.319 | 0.958 | 0.794 |
| rs607755 | A/G | 99 | 1.000 | 37 | 47 | 15 | 0.389 | 160 | 0.182 | 47 | 88 | 25 | 0.431 | 0.429 | 0.342 |
| rs563264 | A/G | 100 | 1.000 | 95 | 5 | 0 | 0.025 | 162 | 0.443 | 150 | 11 | 1 | 0.040 | 0.386 | 0.356 |
| rs540058 | T/C | 98 | 1.000 | 93 | 5 | 0 | 0.026 | 161 | 0.446 | 149 | 11 | 1 | 0.040 | 0.404 | 0.370 |
| rs727708 | A/G | 100 | 0.943 | 30 | 51 | 19 | 0.445 | 160 | 1.000 | 36 | 80 | 44 | 0.475 | 0.184 | 0.076 |
| rs12705141 | A/T | 100 | 0.664 | 74 | 23 | 3 | 0.145 | 161 | 0.747 | 110 | 45 | 6 | 0.177 | 0.528 | 0.338 |
| rs2299356 | A/G | 100 | 0.406 | 34 | 53 | 13 | 0.395 | 161 | 0.880 | 47 | 82 | 32 | 0.453 | 0.344 | 0.190 |
| rs362691f | G/C | 100 | 1.000 | 84 | 15 | 1 | 0.085 | 163 | 1.000 | 121 | 39 | 3 | 0.138 | 0.153 | 0.067 |
| rs123714 | C/T | 100 | 0.763 | 52 | 40 | 10 | 0.300 | 163 | 0.614 | 91 | 64 | 8 | 0.245 | 0.247 | 0.169 |
| rs123713 | C/T | 100 | 0.763 | 50 | 40 | 10 | 0.300 | 161 | 0.899 | 90 | 62 | 9 | 0.248 | 0.339 | 0.196 |
| rs144525 | A/G | 99 | 0.536 | 69 | 29 | 1 | 0.157 | 161 | 0.380 | 101 | 56 | 4 | 0.199 | 0.448 | 0.227 |
| rs362626 | C/A | 100 | 1.000 | 40 | 46 | 14 | 0.370 | 161 | 0.307 | 61 | 82 | 18 | 0.366 | 0.628 | 0.935 |
| rs362814 | A/T | 99 | 0.613 | 41 | 43 | 15 | 0.369 | 161 | 0.497 | 62 | 80 | 19 | 0.366 | 0.521 | 0.959 |
| rs362813 | T/C | 100 | 0.961 | 26 | 49 | 25 | 0.495 | 163 | 0.694 | 47 | 78 | 38 | 0.472 | 0.857 | 0.614 |
| rs362731 | T/C | 100 | 1.000 | 26 | 50 | 24 | 0.490 | 162 | 0.759 | 47 | 78 | 37 | 0.469 | 0.856 | 0.642 |
| rs362726 | T/C | 98 | 0.879 | 24 | 51 | 23 | 0.495 | 163 | 1.000 | 56 | 79 | 28 | 0.414 | 0.189 | 0.072 |
| rs2535764 | C/T | 99 | 0.066 | 68 | 24 | 7 | 0.192 | 163 | 0.352 | 106 | 48 | 9 | 0.202 | 0.647 | 0.769 |
| rs362719 | C/A | 100 | 0.926 | 36 | 47 | 17 | 0.405 | 159 | 0.131 | 74 | 62 | 23 | 0.340 | 0.258 | 0.132 |
| rs2299334 | G/A | 100 | 0.680 | 66 | 32 | 2 | 0.180 | 163 | 1.000 | 104 | 52 | 7 | 0.202 | 0.612 | 0.527 |
| rs11976900 | A/G | 99 | 0.486 | 57 | 34 | 8 | 0.253 | 161 | 0.139 | 92 | 54 | 15 | 0.261 | 0.951 | 0.833 |
| rs2229864f | C/T | 100 | 1.000 | 68 | 29 | 3 | 0.175 | 161 | 0.214 | 104 | 47 | 10 | 0.208 | 0.545 | 0.354 |
aMajor/minor allele, major, and minor alleles are denoted by D and d, respectively. bNumbers of samples that are successfully genotyped in patients and controls, respectively. cp-Values of the Hardy-Weinberg equilibrium (HWE) tests from Haploview v4.2. dThe minor allele frequency of 30 selected SNPs in this study. eUncorrected p-values of allelic and genotypic association analysis in this study. fTwo exonic SNPs selected in this report.