Table 2.
Univariate and Multivariate analyses of the 5-year OS in N0 patients
Variable | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p Value | HR | 95% CI | p Value | |
Age | p < 0.001 | p < 0.001 | ||||
age < 55 | Ref | / | Ref | / | ||
55 ≤ age < 65 | 1.06 | 0.62–1.79 | 1.04 | 0.62–1.80 | ||
age ≥ 65 | 2.48 | 1.59–3.86 | 2.16 | 1.39–3.38 | ||
Sex | p = 0.06 | |||||
female | Ref | / | ||||
male | 0.63 | 0.39–1.02 | ||||
Tumor location | p < 0.001 | |||||
upper third | Ref | / | ||||
middle third | 2.47 | 1.66–3.67 | ||||
lower third | 1.58 | 0.94–2.66 | ||||
Tumor differentiation | p = 0.43 | |||||
well differentiated | Ref | / | ||||
moderately differentiated | 0.84 | 0.54–1.29 | ||||
poorly differentiated or undifferentiated | 0.92 | 0.58–1.45 | ||||
Lymphovascular Invasion | p < 0.001 | p < 0.001 | ||||
no | Ref | / | Ref | / | ||
yes | 3.26 | 2.21–4.83 | 2.47 | 1.64–3.72 | ||
T-stage | p < 0.001 | p < 0.001 | ||||
T1 | Ref | / | Ref | / | ||
T2 | 1.73 | 0.93–3.22 | 1.54 | 0.83–2.88 | ||
T3 | 3.6 | 2.07–6.26 | 2.62 | 1.48–4.64 | ||
T4 | 3.8 | 2.23–6.73 | 3.18 | 1.82–5.59 |