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. 2019 Mar 11;19:216. doi: 10.1186/s12885-019-5416-8

Table 2.

Univariate and Multivariate analyses of the 5-year OS in N0 patients

Variable Univariate Multivariate
HR 95% CI p Value HR 95% CI p Value
Age p < 0.001 p < 0.001
 age < 55 Ref / Ref /
 55 ≤ age < 65 1.06 0.62–1.79 1.04 0.62–1.80
 age ≥ 65 2.48 1.59–3.86 2.16 1.39–3.38
Sex p = 0.06
 female Ref /
 male 0.63 0.39–1.02
Tumor location p < 0.001
 upper third Ref /
 middle third 2.47 1.66–3.67
 lower third 1.58 0.94–2.66
Tumor differentiation p = 0.43
 well differentiated Ref /
 moderately differentiated 0.84 0.54–1.29
 poorly differentiated or undifferentiated 0.92 0.58–1.45
Lymphovascular Invasion p < 0.001 p < 0.001
 no Ref / Ref /
 yes 3.26 2.21–4.83 2.47 1.64–3.72
T-stage p < 0.001 p < 0.001
 T1 Ref / Ref /
 T2 1.73 0.93–3.22 1.54 0.83–2.88
 T3 3.6 2.07–6.26 2.62 1.48–4.64
 T4 3.8 2.23–6.73 3.18 1.82–5.59