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. 2019 Mar 11;20:53. doi: 10.1186/s12931-019-1018-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — LncRNA CASC2 was down-regulated in hypoxia-induced rats and reversed the increase of mPAP and progression of right ventricular hypertrophy caused by hypoxia. (a) The expression of lncRNA CASC2 was detected by qRT-PCR in rat pulmonary arterial tissues. (b) Systemic blood pressure (SBP) was assessed in normoxia and hypoxia-induced rats. (c) Mean pulmonary arterial pressure (mPAP) was detected in normoxia and hypoxia-induced rats. (d) The right ventricular hypertrophy index (RVI) was calculated in normoxia and hypoxia-induced rats. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, compared with normoxia group. **p < 0.01, compared with hypoxia + pcDNA3.1 group