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. 2019 Mar 5;10:180. doi: 10.3389/fphys.2019.00180

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Copyright © 2019 D’Aquila, Zembroski and Buhman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothetical model of CLD metabolism in lean and DIO mice in the postprandial response to a dietary fat challenge. Proteins identified by proteomic analysis in the CLD fraction of enterocytes from lean and DIO mice in the postprandial response to a dietary fat challenge are associated with both anabolic and catabolic processes. Proteins at similar levels in the CLD fraction isolated from lean and DIO mice are in white boxes. Proteins either unique to or at higher levels in the CLD fraction of a diet group are in black boxes. This model supports the hypothesis of a cycle consisting of hydrolysis of stored TAG and concurrent TAG synthesis on CLDs in the postprandial response to a dietary fat challenge.