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. 2019 Jan 28;40:710–716. doi: 10.1016/j.ebiom.2019.01.040

Table 3.

Proportions of variance explained by genetic (a [2]) and non-shared environmental (e [2]) factors for the Horvath and Levine clocks at time 1 and time 2 in the pooled sample of SATSA and LSADT. The genetic and environmental correlations, rA and rE, indicate the extent of overlap in A and E between time 1 and time 2.

a2 e2 Cross-time a2 Cross-time e2 rA rE
Horvath clock Baseline 0·55 (0·34, 0·76) 0·45 (0·24, 0·66) 0·78 (0·51, 1·05) 0·22 (−0·05, 0·49) 0·77 (0·52, 1·03) 0·25 (−0·02, 0·52)
Follow-up 0·51 (0·30, 0·71) 0·49 (0·29, 0·70)
Levine clock Baseline 0·34 (0·04, 0·65) 0·66 (0·35, 0·97) 1·02 (0·50, 1·54) −0·02 (−0·54, 0·50) 0·98 (0·45, 1·51) −0·01 (−0·31, 0·29)
Follow-up 0·41 (0·17, 0·65) 0·59 (0·36, 0·83)

Note. Numbers in parentheses indicate 95% confidence intervals. The analyses were adjusted for sex (0 = male, 1 = female), current smoking status (0 = no, 1 = yes), cohort effects (birth year) and country (0 = Sweden,1 = Denmark).