Table 2.

Differentially methylated CpG sites in primary APS neutrophils compared to healthy controls. Results are arranged in order of absolute change in methylation fraction (Δβ), where negative values represent hypomethylation, and positive values represent hypermethylation.

CGID	Chr	Position (HG19)	Gene	Mean β		Δβ	Adjusted p
				APS	Controls
cg13341454	18	12884064	PTPN2	0.059	0.435	−0.376	4.3E–04
cg24586205	1	222162028	-	0.550	0.234	0.315	4.6E–02
cg23174406	12	97304436	NEDD1	0.248	0.561	−0.312	3.6E–02
cg20927656	12	7863229	DPPA3	0.387	0.665	−0.278	4.5E–02
cg08820231	12	58013687	SLC26A10	0.581	0.324	0.257	3.6E–02
cg07792871	6	29942706	HCG9	0.299	0.526	−0.226	3.6E–02
cgl5415945	6	31627678	C6orf47	0.839	0.613	0.226	3.6E–02
cg27333952	16	1509206	CLCN7	0.490	0.307	0.183	3.4E–02
cg25528199	19	7505344	ARHGEF18	0.696	0.867	−0.171	3.6E–02
cg01962183	16	1507866	CLCN7	0.659	0.491	0.168	3.6E–02
cg22325292	17	80708367	FN3K	0.800	0.647	0.154	3.8E–02
cg07644321	4	2847213	ADD1	0.272	0.124	0.148	3.6E–02
cg22813794	7	75677469	STYXL1; MDH2; MDH2	0.236	0.096	0.140	3.4E–02
cg23773946	20	62327968	TNFRSF6B	0.213	0.352	−0.139	3.6E–02
cg00893875	10	91597593	-	0.389	0.251	0.138	3.6E–02
cg05731801	16	10647200	EMP2	0.154	0.292	−0.138	3.6E–02
cg14964336	4	1523275	-	0.104	0.238	−0.135	3.6E–02
cg23758309	12	97273300	-	0.608	0.476	0.132	3.6E–02
cg04811706	16	55686715	-	0.597	0.728	−0.130	3.6E–02
cg04385631	12	46385625	SFRS2IP	0.161	0.032	0.129	2.0E–07
cg10196532	13	50134640	RCBTB1	0.586	0.458	0.128	3.4E–02
cg05200811	21	47581042	-	0.702	0.575	0.127	2.7E–02
cg22129323	12	6572482	VAMP1	0.201	0.326	−0.125	3.6E–02
cg18505691	6	29723320	-	0.591	0.469	0.122	3.4E–02
cg01775802	14	72945461	RGS6	0.573	0.454	0.119	8.9E–07
cg17910899	13	100218552	-	0.648	0.531	0.117	4.1E–02
cg11345693	17	79170810	AZI1	0.665	0.552	0.113	3.6E–02
cg03084983	2	180294010	-	0.641	0.529	0.112	2.4E–02
cg03100639	16	31483137	TGFB1I1 SNORD115–15	0.458	0.569	−0.111	3.8E–02
cg01393705	15	25457603	SNORD115–21; HBII–52–24	0.527	0.638	−0.111	3.6E–02
cg10692528	12	6605071	NCAPD2	0.458	0.568	−0.110	3.6E–02
cg06484123	19	53107200	-	0.425	0.315	0.110	4.6E–02
cg15555017	11	128455958	ETS1	0.528	0.637	−0.109	2.7E–02
cg07747220	20	3052115	OXT	0.567	0.675	−0.108	3.3E–02
cg12578536	5	43003251	-	0.554	0.449	0.105	1.1E–07
cg14789911	21	47582049	C21orf56	0.777	0.674	0.103	2.1E–02
cg24354818	20	62328094	TNFRSF6B	0.186	0.289	−0.103	3.6E–02
cg16591159	16	31487813	TGFB1I1	0.435	0.333	0.102	3.6E–02
cg01675596	8	145911897	-	0.448	0.346	0.102	3.6E–02
cg07187855	6	30854161	DDR1	0.652	0.551	0.102	3.8E–02
cg13752184	13	100219013	-	0.680	0.578	0.102	3.8E–02
cg 16702083	20	62328427	TNFRSF6B	0.298	0.399	−0.101	4.4E–02

APS, antiphospholipid syndrome.