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. Author manuscript; available in PMC: 2019 Sep 4.
Published in final edited form as: Mol Pharm. 2018 Aug 13;15(9):3881–3891. doi: 10.1021/acs.molpharmaceut.8b00355

Figure 3. Pharmacokinetic Analysis of PEG-Peptides as a Function of Lys Repeat.

Figure 3.

A 1 nmol (0.6 μCi) dose of 125I-PEG-peptide was administered via the tail vein of triplicate mice. At time points of 1–8 hrs, 10 μl of blood was serially sampled from the tail vein and directly gamma counted to determine the concentration 125I-PEG-peptide in blood. The data were fit via Phoenix WinNonlin to determine the β-half-life.