Figure 7. Optimized Low Molecular Weight Scavenger Receptor Inhibitor PEG-Peptides.

The percent of ¹²⁵I-PEG-peptide recovered from the liver at a biodistribution time of 5 min following i.v. administration of triplicate mice under dose escalation of 1–80 nmol is illustrated. The IC₅₀ is determined from the PEG-peptide concentration resulting in 50% saturation of liver uptake, assuming a 2 ml blood volume. The IC₅₀ values of 3–40 μM were derived from fitting the results with R² =0.93, 0.7, 0.82 and 0.82 for panels A-D. A value of p < 0.05 was determined for each PEG-peptides 28, 29, 32, and 33 when comparing 1 and 80 nmol dose.