Table 1:

Altered behaviors in MIA offspring

	P0–7	P8–21	P22–35	P36–60	>P60
Communication deficits	6	14, 21, 47, 63, 70	ND	ND	8, 47
Altered social behavior	ND	ND	Affiliation 80 Recognition 61, 80 Interaction 34, 58	Affiliation 80 Recognition 80 Interaction 82	Affiliation 2, 3, 8, 10, 14, 20, 21, 34, 37, 42, 47, 48, 58, 59, 61, 65, 70, 71 Recognition 21, 42, 58, 61, 65 Interaction 8, 33, 63
Stereotypic/repetitive behavior	ND	ND	ND	58, 63	8, 14, 15, 21, 36, 47, 70, 79
Impaired object recognition	ND	ND	24, 32	42	17, 24, 32, 40, 42, 48, 59, 62, 78
Impaired learning and memory	ND	ND	27, 38, 39	7	16, 27, 37, 45, 50, 56, 60, 61, 65, 68,74, 83
Altered latent inhibition	ND	ND	ND	42, 53	25, 26, 42, 50, 51, 53, 54, 71, 74, 83
Altered drug sensitivity	ND	ND	Amphetamine 55	ND	Amphetamine 12, 22, 26, 28, 50, 54–56, 83 Methamphetamine 62 MK-801 26, 28, 54–56
PPI deficits	ND	ND	ND	42, 69, 78	11, 23, 25, 26, 28, 29, 31, 32, 42, 44, 48–50, 54, 56, 59 62, 66, 67, 71, 73, 74, 77–79, 81
Depressive-like behavior	ND	ND	80	80	2, 5, 9, 10, 18, 57, 58, 64
Altered behavior in open field	ND	ND	78	42, 72, 78	35, 40–43, 72, 74, 75
Anxiety-like behavior	ND	ND	34, 78, 80	34, 78	2, 13, 18, 33, 50, 52, 54, 62, 68, 70, 71, 75
Impaired motor coordination	ND	ND	30	1, 30	1, 81
Altered food hoarding	ND	ND	ND	ND	27, 75
Other P0–7: Reflex impairments 4 Delayed acquisition of the forelimb grasp reflex 6 P8–21: ↓ grip strength; ↓approaches toward maternal nest; impaired associative learning 6 P36–60: ↑ risk assessment in elevated plus maze 42 >P60: Faster acquisition of the delayed alternation task; impaired set shifting 13 Impaired temporal perception 19 ↑ ethanol intake and preference 43 Perseverative behavior 52 ↓ basal home cage activity 68 Altered burrowing and food consumption; impaired balance 75 ↑ latency to initiate sexual behavior 76

ND: not determined

References:

^1-Aavani et al., 2015

^2-Abazyan et al., 2010 (G)

^3-Antonson et al., 2017

^4-Arsenault et al., 2014

^5-Babri et al., 2014

^6-Baharnoori et al., 2010 (L)

^7-Batinić et al., 2016

^8-Bauman et al., 2014

^9-Berger et al., 2018

^10-Bitanihirwe et al., 2010a

^11-Borrell et al., 2002 (L)

^12-Buschert et al., 2016

^13-Canetta et al., 2016

^14-Choi et al., 2016

^15-Coiro et al., 2015

^16-Connor et al., 2012

^17-Coyle et al., 2009 (L)

^18-da Silveira et al., 2017

^19-Deane et al., 2017

^20-Ehninger et al., 2012 (G)

^21-Fernández de Cossío et al., 2017 (L)

^22-Fortier et al., 2004 (L)

^23-Fortier et al., 2007 (L)

^24-Fujita et al., 2016

^25-Garay et al., 2013

^26-Giovanoli et al., 2013 (S)

^27-Giovanoli et al., 2015

^28-Giovanoli et al., 2016a (S)

^29-Giovanoli et al., 2016b (S)

^30-Girard et al., 2009 (L)

^31-Hadar et al., 2017

^32-Han et al., 2016

^33-Hava et al., 2006 (L)

^34-Hsueh et al., 2018

^35-Kirsten et al., 2010

^36-Kirsten et al., 2017

^37-Labouessee et al., 2015

^38-Lanté et al., 2007 (L)

^39-Lanté et al., 2008 (L)

^40-Li et al., 2014

^41-Ling et al., 2009 (L)

^42-Lipina et al., 2013 (G)

^43-Liu et al., 2004 (L)

^44-Luan et al., 2018

^45-MacDowell et al., 2017

^46-Machado et al., 2015

^47-Malkova et al., 2012

^48-Mattei et al., 2017

^49-Meehan et al., 2017

^50-Meyer et al., 2005

^51-Meyer et al., 2006a

^52-Meyer et al., 2006b

^53-Meyer et al., 2006c

^54-Meyer et al., 2008a (G)

^55-Meyer et al., 2008b

^56-Meyer et al., 2008c

^57-Missault et al., 2014

^58-Morais et al., 2018

^59-Mueller et al., 2018

^60-Murray et al., 2017

^61-O’Leary et al., 2014 (G)

^62-Ozawa et al., 2006

^63-Pendyala et al., 2017

^64-Reisinger et al., 2016

^65-Richetto et al., 2017a

^66-Romero et al., 2007 (L)

^67-Romero et al., 2010 (L)

^68-Schaafsma et al., 2017 (L)

^69-Shi et al., 2003

^70-Shin Yim et al., 2017

^71-Smith et al., 2007

^72-Van den Eynde et al., 2014

^73-Vuillermot et al., 2011 (G)

^74-Vuillermot et al., 2012 (G)

^75-Wang et al., 2010 (L)

^76-Wijkstra et al., 1991 (L)

^77-Wischhof et al., 2015a (L)

^78-Wischhof et al., 2015b (L)

^79-Wu et al., 2015

^80-Wu et al., 2018 (L)

^81-Zhang and van Praag, 2015

^82-Zhu et al., 2014

^83-Zuckerman et al., 2003

References noted with (L) used LPS; all others used Poly (I:C) except Arsenault et al., 2014 which compared both immunogens. (G) indicates gene-environment interaction studies. (S) indicates MIA offspring were exposed to peripubertal stress.