Table 4:

Alterations in peripheral cytokines in MIA offspring

Age	Alteration	Immunogen	Reference
P0–7	↑ G-CSF, IFNγ, IL-1β, IL-3, IL-6, IL-12(p40), TNF-α; ↓ GM-CSF, IL-1α, IL- 2, IL-3, IL-12(p70) ⁽¹⁾	20 mg/kg Poly (I:C), i.p.	Garay et al., 2013
P8–21	↑ TNF-α ⁽¹⁾	20 mg/kg Poly (I:C), i.p.	Garay et al., 2013
P8–21	↑ IL-2, IL-5, IL-6 ⁽²⁾	5 mg/kg Poly (I:C), i.v. (3 consecutive days)	Arsenault et al., 2014
P22–35	↑ IL-1β, IL-6, IL-9; Decreased IL-3 ⁽¹⁾	20 mg/kg Poly (I:C), i.p.	Garay et al., 2013
	↓ IL-6, TNF-α ⁽³⁾	5 mg/kg Poly (I:C), i.v.	Pacheco-López et al., 2011
	↑ IL-1β, IL-6 ⁽⁴⁾	25, 25, and 50 μg/kg LPS on 3 consecutive days	Hsueh et al., 2018
P36–60	↑ IL-1β, IL-6, IL-10 ⁽⁴⁾	25, 25, and 50 μg/kg LPS on 3 consecutive days	Hsueh et al., 2018
>P60	↓ IFN-γ, IL-2 ⁽³⁾	5 mg/kg Poly (I:C), i.v.	Pacheco-López et al., 2011
	↑ CCL2, G-CSF, IFNγ, IL-2, IL-6, IL- 13, TNF-α ⁽¹⁾	3 doses of 0.25 mg/kg Poly I:C-LC, i.v.	Rose et al., 2017
	↑ IL-6, IL-17 released by splenic CD4+ T cells upon stimulation ⁽²⁾	20 mg/kg Poly (I:C), i.p.	Hsiao et al., 2012

Abbreviations: CCL: chemokine (C-C motif) ligand; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; IFN: interferon

Superscripts indicate methods used to measure cytokines:

⁽¹⁾

Bead-based multiplex assay

⁽²⁾

Enzyme- linked immunosorbent assay

⁽³⁾

Multiplexed particle-based flow cytometry assay

⁽⁴⁾

Cytometric bead array

For the studies in this table, the immunogen was administered via either intraperitoneal (i.p.) or intravenous (i.v.) injection.