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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Expert Rev Vaccines. 2018 Dec 26;18(1):75–87. doi: 10.1080/14760584.2019.1559063

Fig. 1.

Fig. 1

Measles virus receptor CD46 and functional effects of CD46 rs2724374

The figure above is published with permission from Human Genetics. [126, 127] The extracellular portion of CD46 consists of four N-glycosylated conserved short consensus repeats SCR1-4; a STP region that is O-glycosylated (encoded by exons 7/A, 8/B and 9/C); and a region of unknown function (U). The four most common CD46 isoforms are defined based on the present STP exon/exons and the cytoplasmic tail (CYT1 or CYT2): BC1 and BC2 (with B and C exons/domains in the STP and with either CYT1 or CYT2), and C1 and C2 (with C exon/domain in the STP and with either CYT1 or CYT2). The effect of CD46 rs2724374 on CD46 isoform prevalence (exon B expression or skipping), interaction between CD46 and MV, and immune response following measles vaccination is also summarized for the different genotypes.