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. Author manuscript; available in PMC: 2019 Mar 12.
Published in final edited form as: Sci Transl Med. 2014 Dec 3;6(265):265ra167. doi: 10.1126/scitranslmed.3009500

Fig. 4. CT findings of a patient showing an initial response to therapy followed by emergence of LZD resistance.

Fig. 4.

This subject presented with bilateral, apical disease with the major site of FDG avidity being the left upper lung (yellow and see fig. S5). At one month (left bottom shows the isolated left lung) this site of disease showed a modest reduction in metabolic activity and a slight resolution of CT features consistent with a positive response to therapy but at six months (bottom right) a new lesion (red) emerged anterior and inferior to the initial large apical cavity in the left upper lobe. The patient initially converted their sputum smear and culture to negative but subsequently developed LZD-resistant bacteria that was confirmed genetically to map to the LZD binding site.