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. 2018 Oct 26;21(2):121–130. doi: 10.4103/aja.aja_56_18

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Copyright: © The Author(s)(2018)

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

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The biochemical process networks of the differentially expressed proteins generated by MetaCore™ software using a transcription regulation algorithm. The biochemical process regulation networks were ranked by a value and interpreted in terms of GO. Gene network illustrates proteins and interactions of the differentially expressed proteins. MetaCore™ pathway analysis predicting androgen receptor as the major regulator and pathways involved were; (a) chaperone-mediated stress response; (b) sperm function; (c) proteosomal pathway; and (d) predicted impaired androgen receptor signaling in spermatozoa of infertile patients. GO: gene ontology; F1: least mature stage having the lowest density; F2, F3: intermediate stages; F4: includes the most dense and morphologically mature motile spermatozoa. Full names of abbreviated proteins are presented in Supplementary Information^{(39.6KB, pdf)}.