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. 2019 Feb 10;18(2):e12920. doi: 10.1111/acel.12920

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© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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17aE2 causes a sex‐specific amino acid response in quadriceps that is regulated by gonadal hormones. (a) Metabolites showing a sex‐specific treatment response. Box plots tails show min and max values. (b) Principal component analysis showing amino acid factor loadings for PC1 and sex, treatment and surgery scores for PC1. (c) LC3BII and (d) 4EBP1 abundance in mice of different surgical, sex and treatment status, assessed in whole cell muscle homogenate using western blot. Error bars represent SEM and p values are calculated from a Student's t test. N = 6–8 per group