Figure 2.

Metabolic effects of long‐term hypothalamic BDNF gene transfer. (a) Experimental design. (b) Body weight. (c) Absolute (left) and relative (right) food intake recorded from week 3 to 10 post‐AAV injection. (d) Core rectal temperature measured 12 weeks post injection. (e) Area under the curve (AUC) of (f). (f) Glucose tolerance test at 13 weeks post injection. n = 8–9 for YFP, n = 9–10 for autoBDNF (b) to (f). (g) CLAMS assessment at 20 weeks post injection. Oxygen consumption, respiratory exchange ratio (RER), and physical activity in a 24‐hr period; Shaded area, dark phase. n = 6 per group. Error bars represent mean ± SEM. *p < 0.05. **p < 0.01