Table 1.

Effects of high‐fat diet and alogliptin on blood biomarkers

Parameter	Normal chow (NC)	High‐fat diet (HFD)	Alogliptin + HFD (AHF)
Glucose‐fasted (mM)	6.3 ± 0.9	7.9 ± 2.1*	7.1 ± 1.7
Glucose‐fed (mM)	9.5 ± 1.2	10.9 ± 2.5	10.2 ± 2.2
Insulin (mIU)	13.45 ± 1.84	29.81 ± 2.87*	15.52 ± 2.01#
IGF‐1 (ng/ml)	367 ± 45	402 ± 37	411 ± 33
HbA1c (%)	5.3 ± 0.7	5.7 ± 0.6	5.2 ± 0.9
TG (mM)	1.19 ± 0.15	2.45 ± 0.19*	1.98 ± 0.22* , #
TC (mM)	3.05 ± 0.11	4.71 ± 0.25*	4.66 ± 0.26*
FFA (mM)	0.51 ± 0.03	1.67 ± 0.04*	1.23 ± 0.04* , #
Adiponectin (μg/ml)	11.6 ± 1.5	8.0 ± 1.6*	12.7 ± 2.1#
HDL (mM)	1.59 ± 0.15	1.47 ± 0.12	1.46 ± 0.14
LDL (mg/dl)	49 ± 11	55 ± 15	46 ± 10
Amylase (U/L)	2,220 ± 160	2,450 ± 260	2,190 ± 350
Ala aminotransferase (U/L)	320 ± 71	557 ± 103*	354 ± 89#
Asp aminotransferase (U/L)	491 ± 90	560 ± 78	457 ± 62
Creatinine (mg/dl)	0.47 ± 0.03	0.53 ± 0.04	0.54 ± 0.04
TNF‐α (pg/ml)	31.4 ± 3.9	58.2 ± 5.1*	37.1 ± 4.5#
IL‐6 (pg/ml)	10.8 ± 2.2	16.4 ± 3.5*	14.1 ± 3.1*

Data are expressed as mean ± SD.

FFA: free fatty acid; HDL: high‐density lipoprotein; LDL: low‐density lipoprotein; TC: total cholesterol; TG: triglycerides.

^* p < 0.05 versus NC.

^# p < 0.05 versus HFD.