Table 1.
Effects of three different doses of ACA on lifespan
| Group | N | Median lifespan | Lifespan at 90th percentile | ||||
|---|---|---|---|---|---|---|---|
| Days | % change | p‐value | Days | % change | Wang–Allison p‐value | ||
| Females | |||||||
| Cont_13 | 287 | 889 | 1,097 | ||||
| ACA_lo | 139 | 887 | 0% | 0.03 | 1,123 | 2% | 0.37 |
| ACA_mid | 142 | 933 | 5% | 0.003 | 1,125 | 3% | 0.007 |
| ACA_hi | 152 | 922 | 4% | 0.006 | 1,125 | 3% | 0.10 |
| UA | 147 | 885 | 0% | 0.49 | 1,084 | –1% | 0.46 |
| Cont_12 | 279 | 877 | 1,100 | ||||
| HBX | 136 | 856 | –2% | 0.4 | 1,091 | –1% | NS |
| I767d | 136 | 868 | –1% | 0.8 | 1,102 | 0% | NS |
| Males | |||||||
| Cont_13 | 273 | 830 | 1,089 | ||||
| ACA_lo | 147 | 918 | 11% | <0.0001 | 1,211 | 11% | 0.0004 |
| ACA_mid | 161 | 975 | 17% | <0.0001 | 1,210 | 11% | 0.0004 |
| ACA_hi | 163 | 964 | 16% | <0.0001 | 1,181 | 8% | 0.0001 |
| UA | 151 | 883 | 6% | 0.38 | 1,092 | 0% | 0.91 |
| Cont_12 | 284 | 816 | 1,055 | ||||
| HBX | 155 | 822 | 1% | 0.4 | 1,069 | 1% | NS |
| I767d | 147 | 791 | –3% | 0.11 | 1,012 | –4% | NS |
Lifespans of ITP mice from cohorts 2013 and 2012. Cont_13 = controls for cohort started in 2013; Cont_12 = controls for cohort started in 2012. N = number of mice tested; data were pooled, with about 1/3 from each testing site. Probabilities that lifespans are the same as the controls in column 4 (p‐value) used two‐tailed log‐rank test on pooled data stratified by sites; “removed” mice were included in these calculations. Probabilities that the proportion of live mice is the same in treated as in the control group at the 90th percentile age are evaluated by the procedure of Wang et al., (2004). Amounts of ACA in diet: hi = 2,500 ppm; mid = 1,000 ppm; lo = 400 ppm. UA, HBX, and 1767d had no significant effect on lifespan in the doses used.
NS: not significant.