Table 1.
Pathways predicted to be affected by miRNAs in the X‐chromosomal cluster
| KEGG pathway | p‐Value | Genesa | miRNAsb | RNA‐seq verifiedc |
|---|---|---|---|---|
| PI3K‐AKT signaling pathway | 3.02 x 10−10 | 69 | 14 | 28 |
| mTOR signaling pathway | 2.63 x 10−7 | 17 | 11 | 7 |
| Axon guidance | 2.93 x 10−7 | 30 | 11 | ND |
| GABAergic synapse | 8.26 x 10−7 | 17 | 7 | ND |
| Prostate cancer | 1.57 x 10−6 | 20 | 10 | ND |
| MAPK signaling pathway | 6.77 x 10−6 | 45 | 11 | 9 |
| Dopaminergic synapse | 6.91 x 10−5 | 26 | 10 | ND |
| Glutamatergic synapse | 9.25 x 10−5 | 22 | 8 | ND |
| Wnt signaling pathway | 9.47 x 10−5 | 29 | 9 | 12 |
ND: not determined.
Pathways in bold are known to be altered with age.
a
The number of genes in the pathway that are predicted to be affected by at least one miRNA in the cluster.
b
The number of miRNAs predicted to affect at least one gene in the pathway.
c
The number of predicted genes shown to decrease with age by RNA‐seq.