Table 2.
Selection of naturally occurring variants of HLA optimal epitopes for NU and GP LASV proteins.
| Sequences | Frequency N (%) | HLA-C1 |
HLA-C2 |
HLA-Bw4 |
||||
|---|---|---|---|---|---|---|---|---|
| *C07:01 | C*08:02 | C*06:02 | C*05:01 | B*27:05 | B*53:01 | |||
| NP358 | FPTGLTYSQL | 118 (56.2) | 47 | 15 | 60 | 21 | 37 | 0.12 |
| FTAGLTYSQL | 71 (33.8) | 27 | 8 | 35 | 14 | 19 | 5 | |
| GP420 | YMERQGKTPL | 86 (40.9) | 25 | 0.5 | 33 | 16 | 12 | 21 |
| YIDRQGKTPL | 59 (28.1) | 29 | 0.1 | 36 | 1.5 | 25 | 21 | |
Data are expressed in NetMHCpan percentile rank score; the lower score is associated with the higher predicted affinity. Frequency is based on the 210 NP and GP analyzed sequences. Point-mutations are underlined.