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. 2019 Feb 28;10:116. doi: 10.3389/fimmu.2019.00116

Figure 1.

Figure 1

Distribution of acquired mutations in exon 17 of CSF3R in CN and CN-MDS/AML patients. Schematic representation of exon 17 of the CSF3R gene along with protein sequence (NP_000751.3) showing four conserved tyrosine residues. The amino acid positions corresponding to exon 17 are indicated. The intracellular critical region of CSF3R is marked in red. Amino acid (AA) positions of the CSF3R gene mutations are confined to the region between amino acid residues 715 and 787. Mutations in G-CSFR associated with leukemia and MDS in CN are denoted by “AML” or “pre-B ALL”, *- stop codon. (B) Inter-run reproducibility between CSF3R DNA deep sequencing runs. Inter-run reproducibility was assessed by sequencing of 13 CSF3R mutations from 11 CN patients in two separate runs.