FIGURE 2.

Bradykinin receptor blockade by noscapine alleviates regional hypoperfusion in arcAβ mice. (A) Anatomical position of slice for arterial spin labeling on sagittal T₂-weighted image (top) and representative regions of interest (ROI) [cortex (red), hippocampus (yellow), and thalamus (blue)] on coronal T₂-weighted anatomical image acquired at the same position (bottom). (B) Representative coronal CBF maps (approximately Bregma –1.5 ± 0.3 mm) of untreated and noscapine-NTLs and arcAβ mice, respectively. (C) Quantification of regional CBF showed hypoperfusion in the cortex and thalamus of arcAβ compared with NTLs that is mitigated by noscapine treatment. Data are present as mean ± standard deviation; ^∗p < 0.05, ^∗∗p < 0.01, two-way ANOVA with post hoc Turkey’s correction for multiple comparison; CBF, cerebral blood flow. NTL (n = 8), NTL noscapine (n = 9), arcAβ (n = 9), arcAβ noscapine (n = 11).