Table 1.

Summary of SCS macrophages in different studies.

Model	Cytokines	Recruited cells	SCS macrophages	Depletion method	References
VIRUSES
VSV	IFN-α, IFN-I	B cells, Plasmacytoid dendritic cells	–	CLL CD11c-DTR	(11, 33, 34)
Adenovirus	–	B cells	–	CLL	(11)
MCMV	–	–	–	CLL CD169-DTR	(35)
Influenza virus	IL-1α IFN-β	B cells NK cells Neutrophils	MS DCs, MS macrophages Necrosis	CLL CD169-DTR	(39, 40)
CpG	–	Dendritic Cells B cells	Dissociation, CCR7 dependent migration	CLL	(50)
BACTERIA
Pseudomonas aeruginosa	IFN-γ IL-18 IL-1β	NK cells γδ T cells NKT cells αβ TCR CD8+ T cells Neutrophils	–	CLL	(36)
Staphylococcus aureus	C5aR	Neutrophils	Dissociation	CLL	(47, 50)
Lipid antigens (α-galactosylceramide coated on silica particles)	CD1d IL-2 IFN-γ	iNKT cells	Dissociation	CLL	(37, 50)
Glycolipids (α-linked galacturonic glycosphingolipid on silica particles)	–	iNKT cells	–	CLL	(37)
LPS	–	Dendritic Cells B cells	Dissociation, CCR7 dependent migration	CLL	(50)
PARASITES
Toxoplasma gondii	IFN-γ	NK cells	Dissociation	CLL	(45, 49)
QS-21 (Malariacomponent)	IL-1β	Monocytes Neutrophils Eosinophils Dendritic cells		CLL	(46)
CANCER
Exosomes	–	CD4+ T cells CD8+ T cells	–	CD169−/−	(38, 56)
Irradiated tumor cells	IFN-γ	CD8+ T cells		CD169-DTR	(12)
Melanoma and melanoma-derived exosomes	–	Follicular DCs B cells	Dissociation	CLL CD169-DTR	(15, 54)
OTHER DISEASES
Colitis	IL-17, IL-21, IL-23, IL-6, IL-1β, TNFα, IL-12, IL-18, CCL8, CCL3	Th17 cells	Increase	CD169-DTR	(55)