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. 2019 Feb 27;10:171. doi: 10.3389/fphys.2019.00171

Table 2.

Differential metabolites in pig livers in the AM, FMT, and CO groups on day 21.

Metabolites Biological roles Metabolic subpathway FC1 VIP2 P-value3
AM/CO Glutamine Amino acid Arginine biosynthesis 3.9 2.089 0.001
S-methyl-Cysteine Amino acid Others 1.25 1.475 0.035
Asparagine Amino acid Alanine, aspartate and glutamate metabolism 1.77 2.102 0.001
Pyroglutamic acid Amino acid Glutathione metabolism 0.822 1.883 0.006
Uridine-5-monophosphate nucleoside Pyrimidine metabolism 3.09 1.857 0.004
Adenosine-5-monophosphate nucleoside Purine metabolism 0.305 1.843 0.009
Arachidonic acid Unsaturated fatty acids Arachidonic acid metabolism 1.38 2.044 0.001
9,12-(Z,Z)-Octadecadienoic acid Unsaturated fatty acids Linoleic acid metabolism 1.3 1.853 0.007
9-(Z)-Octadecenoic acid Unsaturated fatty acids Fatty acid biosynthesis 1.25 1.739 0.014
Octadecanoic acid Saturated fatty acids Fatty acid biosynthesis 1.24 1.849 0.007
Hexadecanoic acid Saturated fatty acids Fatty acid biosynthesis 1.24 1.7 0.026
2-Hydroxyglutaric acid Organates/carboxylates Others 0.789 1.72 0.013
Pyruvic acid Organates/carboxylates Pyruvate metabolism 0.727 1.917 0.006
Sorbitol-6-phosphate Carbohydrate Fructose and mannose metabolism 1.22 2.041 0.001
Phosphoric acid Oxidative phosphorylation relatives Oxidative phosphorylation 0.893 1.508 0.048
FMT/CO Glutamine Amino acid Arginine biosynthesis 8.6 1.865 <0.001
Asparagine Amino acid Alanine, aspartate and glutamate metabolism 2.96 1.947 <0.001
Methionine Amino acid Cysteine and methionine metabolism 1.59 1.566 0.017
Ornithine Amino acid Arginine biosynthesis 1.56 1.429 0.033
S-methyl-Cysteine Amino acid Others 1.38 1.48 0.019
Arachidonic acid Unsaturated fatty acids Arachidonic acid metabolism 1.56 1.737 0.003
9,12-(Z,Z)-Octadecadienoic acid Unsaturated fatty acids Linoleic acid metabolism 1.49 1.672 0.006
9-(Z)-Octadecenoic acid Unsaturated fatty acids Fatty acid biosynthesis 1.44 1.594 0.013
Hexadecanoic acid Saturated fatty acids Fatty acid biosynthesis 1.44 1.758 0.003
Octadecanoic acid Saturated fatty acids Fatty acid biosynthesis 1.4 1.917 <0.001
1-Monooctadecanoylglycerol Lipid Others 1.33 1.608 0.008
Glyceric acid-3-phosphate Lipid Glycolysis or Gluconeogenesis 0.768 1.375 0.023
Hypoxanthine Nucleoside Purine metabolism 2.04 1.57 0.013
Adenosine-5-monophosphate Nucleoside Purine metabolism 0.122 1.679 0.002
Sorbitol-6-phosphate Carbohydrate Fructose and mannose metabolism 1.24 1.853 <0.001
Phosphoric acid Oxidative phosphorylation relatives Oxidative phosphorylation 0.864 1.407 0.018
Pyruvic acid Organates/carboxylates Pyruvate metabolism 0.704 1.613 0.005
FMT/AM Glutamine Amino acid Arginine biosynthesis 2.2 1.823 0.00426
Asparagine Amino acid Alanine, aspartate and glutamate metabolism 1.68 1.92 0.00143
Glycine Amino acid Glycine, serine and threonine metabolism 1.49 1.453 0.0348
Methionine Amino acid Cysteine and methionine metabolism 1.45 1.635 0.0165
Alanine Amino acid Alanine, aspartate and glutamate metabolism 1.28 1.506 0.0312
Ribose Carbohydrate Pentose phosphate pathway 1.17 1.539 0.0287
Maltose Carbohydrate Starch and sucrose metabolism 2.07 1.721 0.00998
Galactose Carbohydrate Galactose metabolism 0.94 1.599 0.023
Glucose Carbohydrate Glycolysis or Gluconeogenesis 0.94 1.599 0.023
Adenosine nucleoside Purine metabolism 0.666 1.55 0.028
Uridine-5-monophosphate Nucleoside Pyrimidine metabolism 0.662 1.674 0.0125
Adenosine-5-monophosphate Nucleoside Purine metabolism 0.402 1.654 0.0183
Octadecanoic acid Saturated fatty acids Fatty acid biosynthesis 1.13 1.518 0.0321
1-Monooctadecanoylglycerol Lipid Others 1.17 1.548 0.0285

1FC = fold change for concentration of metabolites derived from AM, FMT and CO groups. 2VIP = variable importance projection. This value was got from PLS-DA model with a threshold of 1. 3The significance P-value was got from Wilcoxon rank sum test with a threshold of 0.05.