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Effect of 78c on infarct size. Infarct size was measured after 30-minute ischemia/120-minute reperfusion in hearts dosed preischemia with vehicle (0.1% DMSO) or 1, 2.5, 5, 10, or 50 μM 78c. 78c at 2.5, 5, 10, and 50 μM levels significantly decreased infarct size compared with vehicle. *P < 0.05; ***P < 0.001 vs. vehicle (mean ± S.E.M., n = 5–9).
