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Endothelial levels of NADP(H) in WT hearts. Endothelial levels of NADP(H) were measured by HPLC after Triton X-100 permeabilization of coronary endothelium and collection of coronary effluent. NADP(H) was depleted ∼80% in vehicle-treated hearts undergoing I/R. In 10 μM 78c–treated hearts, only ∼20% depletion of NADP(H) occurred, likely through inhibition of CD38. ***P < 0.001 vs. control; †††P < 0.001 vs. control (mean ± S.E.M., n = 4).
