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Representative chromatograms of CD38 substrates and products from hearts. CD38 substrates NAD(P)+ and products (2′-P-)ADPR and nicotinamide (nico) were measured by HPLC in hearts undergoing control perfusion (control) (A), I/R (B), or I/R plus 10 μM 78c (I/R + 78c) (C). Representative chromatograms for each are shown (A–C), along with a chromatogram of a standard mixture of 50 μM of each analyte (D).
