Skip to main content
. 2019 Apr;369(1):55–64. doi: 10.1124/jpet.118.254557

Fig. 8.

Fig. 8.

Tissue nucleotide levels. (A) NAD(P)+ and (2′-P-)ADPR levels. With I/R, levels of NAD(P)+ decreased compared with the control, with increased levels of CD38 enzymatic products (2′-P-)ADPR. Preischemic treatment with 10 μM 78c prevented the NAD(P)+ depletion and enhanced (2′-P-)ADPR production seen with I/R. (B) ATP, ADP, and AMP levels. With I/R, ATP and ADP levels fell greater than 50% and 30%, respectively, in vehicle-treated hearts compared with nonischemic controls. Postischemic levels of these nucleotides were higher in 78c-treated hearts, consistent with increased recovery of left ventricular function. AMP levels were unaffected by I/R. *P < 0.05 vs. control; ***P < 0.001 vs. control; †P < 0.05 vs. I/R; †††P < 0.001 vs. I/R (mean ± S.E.M., n = 5).