Figure 1. Top 18 GO functions of DEGs for each species by genotype.

The gene set enrichment analyses (P < 0.1 for all, FDR corrected) identified (A) 1,307 GO terms in human lesional NVUs, (B) 1,565 in Ccm1/Krit1^ECKO BMECs, (C) 519 in C. elegans with a ccm1/kri-1 mutation, (D) 283 in Ccm3/Pdcd10^ECKO BMECs, and (E) 685 in C. elegans ccm3/pdcd10. The DEGs were defined as FC greater than or equal to 1.2, with P less than 0.05 (FDR corrected), for all the models. For display purposes, only the top GOs are presented in each category (BP, MF, and CC) by their respective proportion. BP, biological processes; MF, molecular functions; CC, cellular components; ncRNA, noncoding RNA; and SRP, signal recognition particle. Gene ratio is reported at the end of each respective GO.