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. 2019 Feb 7;4(3):e123971. doi: 10.1172/jci.insight.123971

Figure 5. EBI2 is overexpressed in human BOS and mouse lymphocytic bronchiolitis.

Figure 5

(A) Left lungs from C57BL/6J (B6) and HLA-A2–knockin (HLA) mice on a B6 background (HLA) were removed from the donors, cuffed, and orthotopically transplanted into B6 recipient mice. The mice were analyzed 2 months after LTx. Representative double immunofluorescence stainings for the B cell marker CD45R (green) and EBI2 (83): single channel and merged images. (B) Representative double immunofluorescence stainings of human bronchiolitis obliterans syndrome (BOS) explants for the T cell marker CD3 (top, green), the B cell marker CD20 (top, red), the germinal center marker GL7 (bottom, green), and EBI2 (bottom, red). Single channel and merged images. Scale bars: 100 μm.