Figure 4. Quetiapine induces hypercholesterolemia in both PXR^fl/fl and PXR^ΔHep mice.

(A) qPCR analysis of PXR mRNA levels in liver and intestine of PXR^fl/fl and PXR^ΔHep mice (n = 5, Student’s t test, *P < 0.05). (B–E) Eight-week-old male PXR^fl/fl and PXR^ΔHep littermates were treated with vehicle control or 10 mg/kg/day of quetiapine by oral gavage for 1 week. Body weight (B), fasting plasma total cholesterol (C), and triglyceride (D) levels were measured. Lipoprotein fractions (VLDL, LDL, and HDL) were isolated, and the cholesterol levels of each fraction were measured (E) (n = 6–7, 2-way ANOVA, *P < 0.05 and **P < 0.01).