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. 2019 Feb 7;4(3):e125657. doi: 10.1172/jci.insight.125657

Figure 5. Quetiapine-mediated PXR activation stimulates NPC1L1 and MTP expression in the intestine of PXRfl/fl but not PXRΔIEC mice.

Figure 5

Eight-week-old male PXRfl/fl and PXRΔIEC littermates were treated with vehicle control or 10 mg/kg/day of quetiapine for 1 week. (A and B) Intestinal expression of PXR target genes (A) and lipogenic genes (B) were measured by qPCR (n = 5–6, Student’s t test, *P < 0.05 and ***P < 0.001). (C–E) Immunoblotting for NPC1L1 and MTP proteins (C) and representative immunofluorescence staining for NPC1L1 (D) and MTP (E) proteins in the intestine of control or quetiapine-treated PXRfl/fl and PXRΔIEC mice (n = 3–5). Scale bars: 100 μM.