Table 2.
Significant difference between different groups in global functional connectivity density (gFCD).
| Brain regions | MNI coordinates | Voxel size | Peak T value | ||
|---|---|---|---|---|---|
| x | y | z | |||
| PRETREATMENT vs. CONTROL | |||||
| Increased gFCD | |||||
| Middle insula (left) | −36 | 6 | 3 | 234 | 4.93 |
| Posterior middle insula (right) | 39 | −3 | 3 | 310 | 4.87 |
| Supramarginal gyrus (left) | −63 | −51 | 30 | 296 | 5.68 |
| Dorsal medial prefrontal cortex(DMPFC) (left) | −9 | 54 | 42 | 154 | 5.42 |
| Decreased gFCD | |||||
| No | |||||
| POST-TREATMENT vs. PRETREATMENT | |||||
| Increased gFCD | |||||
| Perigenual anterior cingulate cortex (pgACC) (left) | −12 | 45 | 12 | 231 | 4.16 |
| Right supramarginal gyrus (right) | 54 | −63 | 33 | 470 | 4.78 |
| Orbitofrontal cortex (left) | −24 | 57 | 3 | 217 | 3.97 |
| Decreased gFCD | |||||
| aRight insula (right) | 36 | −15 | 6 | 110 | −4.03 |
a
Results are P < 0.05, corrected for multiple comparisons at a cluster level with AlphaSim, with an underlying voxel level of P < 0.001, uncorrected under whole brain analyses.