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. 2019 Mar 7;14:1753–1777. doi: 10.2147/IJN.S176013

Figure 9.

Figure 9

Modulatory role of PPE-AuNP on STZ-induced MAPK-guided NF-κB/STAT3 pathway activation in renal tissue. (A, C, E) Representative immunoblots of p-Raf1, total Raf1, p-ERK1/2, total ERK1/2, p-TAK1, total TAK1, p-p38, total p38, p-IKKα/β, total IKKα/β, p-IκBα, total IκBα, p-p65, total p65, p-p50, total p50, p-STAT3, and total STAT3. (B, D, F) Densitometric analysis of relative protein expression of p-Raf1, total Raf1, p-ERK1/2, total ERK1/2, p-TAK1, total TAK1, p-p38, total p38, p-IKKα/β, total IKKα/β, p-IκBα, total IκBα, p-p65, total p65, p-p50, total p50, p-STAT3, and total STAT3. β-Actin was served as internal control. Values are presented as mean ± SEM (n=6). P<0.05 was considered as significant. Statistical comparison: *Control vs STZ; **STZ vs STZ + PPE-AuNP (5 mg/kg); ***STZ vs STZ + PPE-AuNP (15 mg/kg); #STZ vs STZ + PPE-AuNP (25 mg/kg).

Abbreviations: AuNP, gold nanoparticle; NS, nonsignificant; PPE, pomegranate peel extract; SEM, standard error of mean; STZ, streptozotocin.