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. 2019 Jan 24;4(2):e121905. doi: 10.1172/jci.insight.121905

Figure 6. GL-2045 transiently modulates circulating cytokine levels in NHPs.

Figure 6

I.v. infusion of GL-2045 decreased IL-8 (A) and increased IL-1RA and IL-10 (B) in the circulation of NHPs. GL-2045 was infused i.v. at different doses in 2 separate studies. Blood samples were collected preinfusion (0 hours) and at 1, 3, and 24 hours after initiation of the i.v. infusion, and serum levels of cytokines were assessed. Data from blood collected during the first 24 hours after infusion are shown as least squares means. The bounds of the boxes represent the 25th and 75th percentile, the lines represent median, top and bottom whiskers represent the 95th and 5th percentile, and the circles are the values above 95th percentile. Low-dose study: n = 6 animals per group. High-dose study: n = 9, 0 mg/kg; n = 6, GL-2045, 50 mg/kg; n = 6, GL-2045, 224 mg/kg; n = 10, GL-2045, 1000 mg/kg. *P < 0.05, **P < 0.01, ***P < 0.001, compared with preinfusion levels (0 hours).