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. 2018 Mar 15;518:210–220. doi: 10.1016/j.virol.2018.02.022

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© 2018 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 7 — Neutralizing antibody titers produced by cotton rats after inoculation with recombinant MV. Cotton rats were intranasally inoculated with 1.0 × 10⁶ PFU of rMV-Hu191 or rMV-Hu191 mutants in 0.1 ml of Opti-MEM medium. (A) Weekly blood samples were collected from each cotton rat by facial vein retro-orbital bleeding, and serum was tested for neutralizing antibodies by a plaque-reduction neutralization assay. (B) Recombinant MVs carrying mutations in the SAM binding site elicited significantly higher levels (p < 0.05) of neutralizing antibodies at 4 weeks post-inoculation. * =p < 0.05; * *=p < 0.01; *** =p < 0.001.