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. Author manuscript; available in PMC: 2019 Mar 12.
Published in final edited form as: J Med Chem. 2017 Apr 19;60(9):3814–3827. doi: 10.1021/acs.jmedchem.7b00018

Figure 5.

Figure 5

Seven-day survival curves for wild-type mice subjected to CLP. One group of wild-type mice (n = 10) was treated with the GlyΨ{PO2H-CH2}Ile-His-Lys-Gln THPI (10 mg/kg) immediately after CLP and then every 12 h for an additional 5 doses (black line). The other group of wild-type mice (n = 10) was treated with saline vehicle using the identical schedule (gray line). None of the nontreated wild-type mice survived CLP after 7 days, while 70% of the wild-type mice treated with the THPI survived after 7 days. p < 0.05; Kaplan−Meier survival analysis.