. Author manuscript; available in PMC: 2019 Mar 12.

Published in final edited form as: J Med Chem. 2017 Apr 19;60(9):3814–3827. doi: 10.1021/acs.jmedchem.7b00018

Table 1. Inhibition of MMP-2 and MMP-9.

enzyme	inhibitor	temperature (°C)	K_i^(app) (nM)
MMP-2	C₆-α1(V)GlyΨ{PO₂H-CH₂}Val THPI	10	4.14 ± 0.47^a
MMP-2	C6-α1(V)GlyΨ{PO₂H-CH₂}Val THPI	37	19.23 ± 0.64^a
MMP-2	α1(V)GlyΨ{PO₂H-CH₂}Val [mep_14,32,Flp_15,33] THPI	25	189.1 ± 26.54
	α1(V)GlyΨ{PO₂H-CH₂}Val [mep_14,32,Flp_15,33] THPI	37	2.24 ± 0.11
MMP-9	C₆-α1(V)GlyΨ{PO₂H-CH₂}Val THPI	10	1.76 ± 0.05^a
	C₆-α1(V)GlyΨ{PO₂H-CH₂}Val THPI	37	1.29 ± 0.00^a
MMP-9	α1(V)GlyΨ{PO₂H-CH₂}Val [mep_14,32,Flp_15,33] THPI	25	90.6 ± 6.67
MMP-9	α1(V)GlyΨ{PO₂H-CH₂}Val [mep_14,32,Flp_15,33] THPI	37	0.98 ± 0.092

As previously published.¹²