Table 2.

Genes potentially of particular interest in the intestine (and spleen) from NE studies.

Gene symbol	Description	Function	General response2
TCF121	Transcription factor 12	Direct DNA (E-box) binding and suppresses E-cadherin expression	↓
BCL21	B-cell CLL/lymphoma 2	Apoptosis regulator	↓
IRF21	Interferon regulatory factor 2	Competitively inhibits the IRF1-mediated transcriptional activation of IFN-α and IFN-β	↓
APP	Amyloid beta (A4) precursor protein	Encodes cell surface receptor and transmembrane precursor protein	↓
TRAF31	TNF receptor-associated factor 3	Crucial regulator suppressing c-Jun N-terminal kinase and NFκB signaling, but facilitates type I interferon production	↓
TAB3	TGF-beta-activated kinase 1/MAP3K7-binding protein 3	NFκB signal transduction pathway	↓
SERPINF11	Serpin peptidase inhibitor, clade F, member 1	Heterophil (elastase) inhibitor	↓
ARHGEF61	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	Role in cellular processes initiated by extracellular stimuli working through G protein coupled receptors.	↓
HSP90B1	Heat shock protein 90 kDa beta (Grp94)	Assists folding, maintenance, and degradation of proteins, and protects from excess heat	↓
TNFRSF11B1	Tumor necrosis factor receptor superfamily, member 11b	Inhibition of osteoclast differentiation and activity	↓
CALB11	Calbindin 1, 28 kDa	Calcium binding and transport	↑

Based on data from Dinh et al., 2014; Hong et al., 2014; Kim et al., 2014; Kim et al., 2015.

¹Includes spleen.

²Significant or >2-fold difference in expression for more resistant phenotype vs. susceptible.